Comparative Computational Studies of 3,4-Dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile Derivatives as Potential Antinociceptive Agents

In this study, the antinociceptive properties of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives 5a–i at doses of 25 and 50 mg/kg were evaluated in mice, using the abdominal constriction test. Molecular modeling studies were also performed using density functional theory calculati...

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Detalles Bibliográficos
Autores principales: dos Anjos, Janaína V., Srivastava, Rajendra M., Costa-Silva, João H., Scotti, Luciana, Scotti, Marcus T., Wanderley, Almir G., Leite, Elisa Soares, de Melo, Sebastião J., Mendonça Junior, Francisco J. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268915/
https://www.ncbi.nlm.nih.gov/pubmed/22249410
http://dx.doi.org/10.3390/molecules17010809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268915/
https://www.ncbi.nlm.nih.gov/pubmed/22249410
http://dx.doi.org/10.3390/molecules17010809

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