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Comparative Computational Studies of 3,4-Dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile Derivatives as Potential Antinociceptive Agents
In this study, the antinociceptive properties of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives 5a–i at doses of 25 and 50 mg/kg were evaluated in mice, using the abdominal constriction test. Molecular modeling studies were also performed using density functional theory calculati...
Autores principales: | dos Anjos, Janaína V., Srivastava, Rajendra M., Costa-Silva, João H., Scotti, Luciana, Scotti, Marcus T., Wanderley, Almir G., Leite, Elisa Soares, de Melo, Sebastião J., Mendonça Junior, Francisco J. B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268915/ https://www.ncbi.nlm.nih.gov/pubmed/22249410 http://dx.doi.org/10.3390/molecules17010809 |
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