Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications

Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Yue, Yu, Peilin, Jin, Hongwei, Yang, Zhenjun, Yue, Jianbo, Zhang, Liangren, Zhang, Lihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268930/
https://www.ncbi.nlm.nih.gov/pubmed/22491682
http://dx.doi.org/10.3390/molecules17044343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268930/
https://www.ncbi.nlm.nih.gov/pubmed/22491682
http://dx.doi.org/10.3390/molecules17044343

Ejemplares similares