Cargando…
Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications
Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed tha...
Autores principales: | Zhou, Yue, Yu, Peilin, Jin, Hongwei, Yang, Zhenjun, Yue, Jianbo, Zhang, Liangren, Zhang, Lihe |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268930/ https://www.ncbi.nlm.nih.gov/pubmed/22491682 http://dx.doi.org/10.3390/molecules17044343 |
Ejemplares similares
-
Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
por: Huang, Xiangchen, et al.
Publicado: (2010) -
Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor
por: Moreau, Christelle, et al.
Publicado: (2011) -
cADPR Does Not Activate TRPM2
por: Riekehr, Winnie Maria, et al.
Publicado: (2022) -
Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?
por: Fliegert, Ralf, et al.
Publicado: (2020) -
Selective inhibition of TRPM2 channel by two novel synthesized ADPR analogues
por: Luo, Xiao, et al.
Publicado: (2017)