Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents

Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light...

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Autores principales: Chou, Shang-Shing P., Juan, Jui-Chi, Tsay, Shwu-Chen, Huang, Kuei Pin, Hwu, Jih Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268963/
https://www.ncbi.nlm.nih.gov/pubmed/22421791
http://dx.doi.org/10.3390/molecules17033370
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author Chou, Shang-Shing P.
Juan, Jui-Chi
Tsay, Shwu-Chen
Huang, Kuei Pin
Hwu, Jih Ru
author_facet Chou, Shang-Shing P.
Juan, Jui-Chi
Tsay, Shwu-Chen
Huang, Kuei Pin
Hwu, Jih Ru
author_sort Chou, Shang-Shing P.
collection PubMed
description Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed.
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spelling pubmed-62689632018-12-20 Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents Chou, Shang-Shing P. Juan, Jui-Chi Tsay, Shwu-Chen Huang, Kuei Pin Hwu, Jih Ru Molecules Article Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed. MDPI 2012-03-15 /pmc/articles/PMC6268963/ /pubmed/22421791 http://dx.doi.org/10.3390/molecules17033370 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chou, Shang-Shing P.
Juan, Jui-Chi
Tsay, Shwu-Chen
Huang, Kuei Pin
Hwu, Jih Ru
Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents
title Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents
title_full Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents
title_fullStr Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents
title_full_unstemmed Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents
title_short Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents
title_sort oxime esters of 2,6-diazaanthracene-9,10-dione and 4,5-diazafluoren-9-one as photo-induced dna-cleaving agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268963/
https://www.ncbi.nlm.nih.gov/pubmed/22421791
http://dx.doi.org/10.3390/molecules17033370
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