(E)-5-Styryl-1H-indole and (E)-6-Styrylquinoline Derivatives Serve as Probes for β-Amyloid Plaques

We report the synthesis and biological evaluation of novel (E)-5-styryl-1H-indole and (E)-6-styrylquinoline derivatives as probes for imaging β-amyloid (Aβ) plaques. These derivatives showed binding affinities for Aβ(1–40) aggregates with K(i) values varying from 4.1 to 288.4 nM. (E)-5-(4-iodostyryl...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Jia, Hong-Mei, Liu, Bo-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268995/
https://www.ncbi.nlm.nih.gov/pubmed/22491675
http://dx.doi.org/10.3390/molecules17044252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268995/
https://www.ncbi.nlm.nih.gov/pubmed/22491675
http://dx.doi.org/10.3390/molecules17044252

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