A Novel Class of Selective Acetylcholinesterase Inhibitors: Synthesis and Evaluation of (E)-2-(Benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles

(E)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles are described as a new class of selective inhibitors of acetylcholinesterase (AChE). The most potent compound in the series exhibited good AChE inhibitory activity (IC(50) = 64 µM). Compound 7f was found to be more selective than galanthamine i...

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Detalles Bibliográficos
Autores principales: de la Torre, Pedro, Saavedra, Luis Astudillo, Caballero, Julio, Quiroga, Jairo, Alzate-Morales, Jans H., Cabrera, Margarita Gutiérrez, Trilleras, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269038/
https://www.ncbi.nlm.nih.gov/pubmed/23085657
http://dx.doi.org/10.3390/molecules171012072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269038/
https://www.ncbi.nlm.nih.gov/pubmed/23085657
http://dx.doi.org/10.3390/molecules171012072

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