Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives

A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent...

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Autores principales: Sorra, Kumaraswamy, Chang, Chi-Fen, Pusuluri, Srinivas, Mukkanti, Khagga, Laiu, Min-Chiau, Bao, Bo-Ying, Su, Chia-Hao, Chuang, Ta-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269039/
https://www.ncbi.nlm.nih.gov/pubmed/22832878
http://dx.doi.org/10.3390/molecules17088762
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author Sorra, Kumaraswamy
Chang, Chi-Fen
Pusuluri, Srinivas
Mukkanti, Khagga
Laiu, Min-Chiau
Bao, Bo-Ying
Su, Chia-Hao
Chuang, Ta-Hsien
author_facet Sorra, Kumaraswamy
Chang, Chi-Fen
Pusuluri, Srinivas
Mukkanti, Khagga
Laiu, Min-Chiau
Bao, Bo-Ying
Su, Chia-Hao
Chuang, Ta-Hsien
author_sort Sorra, Kumaraswamy
collection PubMed
description A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.
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spelling pubmed-62690392018-12-12 Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives Sorra, Kumaraswamy Chang, Chi-Fen Pusuluri, Srinivas Mukkanti, Khagga Laiu, Min-Chiau Bao, Bo-Ying Su, Chia-Hao Chuang, Ta-Hsien Molecules Article A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells. MDPI 2012-07-25 /pmc/articles/PMC6269039/ /pubmed/22832878 http://dx.doi.org/10.3390/molecules17088762 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Sorra, Kumaraswamy
Chang, Chi-Fen
Pusuluri, Srinivas
Mukkanti, Khagga
Laiu, Min-Chiau
Bao, Bo-Ying
Su, Chia-Hao
Chuang, Ta-Hsien
Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives
title Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives
title_full Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives
title_fullStr Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives
title_full_unstemmed Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives
title_short Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives
title_sort synthesis and cytotoxicity testing of new amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (pbdt) derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269039/
https://www.ncbi.nlm.nih.gov/pubmed/22832878
http://dx.doi.org/10.3390/molecules17088762
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