Experimental Methodologies and Evaluations of Computer-Aided Drug Design Methodologies Applied to a Series of 2-Aminothiophene Derivatives with Antifungal Activities

Fifty 2-[(arylidene)amino]-4,5-cycloalkyl[b]thiophene-3-carbonitrile derivatives were screened for their in vitro antifungal activities against Candida krusei and Cryptococcus neoformans. Based on experimentally determined minimum inhibitory concentration (MIC) values, we conducted computer-aided dr...

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Detalles Bibliográficos
Autores principales: Scotti, Luciana, Tullius Scotti, Marcus, de Oliveira Lima, Edeltrudes, Sobral da Silva, Marcelo, do Carmo Alves de Lima, Maria, da Rocha Pitta, Ivan, Olímpio de Moura, Ricardo, Gonzaga Batista de Oliveira, Jaismary, Duarte da Cruz, Rayssa Marques, Bezerra Mendonça, Francisco Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269054/
https://www.ncbi.nlm.nih.gov/pubmed/22367025
http://dx.doi.org/10.3390/molecules17032298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269054/
https://www.ncbi.nlm.nih.gov/pubmed/22367025
http://dx.doi.org/10.3390/molecules17032298

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