Phenylmethimazole Blocks dsRNA-Induced IRF3 Nuclear Translocation and Homodimerization

Previous studies revealed that phenylmethimazole (C10) inhibits IRF3 signaling, preventing dsRNA-induction of type 1 interferon gene expression, production, and downstream signaling. In the present study, we investigated the molecular basis for C10 inhibition of dsRNA-stimulated IRF3 signaling. IRF-...

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Detalles Bibliográficos
Autores principales: Courreges, Maria C., Kantake, Noriko, Goetz, Douglas J., Schwartz, Frank L., McCall, Kelly D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269055/
https://www.ncbi.nlm.nih.gov/pubmed/23090018
http://dx.doi.org/10.3390/molecules171012365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269055/
https://www.ncbi.nlm.nih.gov/pubmed/23090018
http://dx.doi.org/10.3390/molecules171012365

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