EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

Mammals encode ∼5,000 integral membrane proteins that need to be inserted in a defined topology at the endoplasmic reticulum (ER) membrane by mechanisms that are incompletely understood. Here, we found that efficient biogenesis of β1-adrenergic receptor (β1AR) and other G protein-coupled receptors (...

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Detalles Bibliográficos
Autores principales: Chitwood, Patrick J., Juszkiewicz, Szymon, Guna, Alina, Shao, Sichen, Hegde, Ramanujan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269167/
https://www.ncbi.nlm.nih.gov/pubmed/30415835
http://dx.doi.org/10.1016/j.cell.2018.10.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269167/
https://www.ncbi.nlm.nih.gov/pubmed/30415835
http://dx.doi.org/10.1016/j.cell.2018.10.009

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