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Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization—A Job for the Humble Heterogeneity Statistic?

Mendelian randomization (MR) is gaining in recognition and popularity as a method for strengthening causal inference in epidemiology by utilizing genetic variants as instrumental variables. Concurrently with the explosion in empirical MR studies, there has been the steady production of new approache...

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Detalles Bibliográficos
Autores principales: Bowden, Jack, Hemani, Gibran, Davey Smith, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269239/
https://www.ncbi.nlm.nih.gov/pubmed/30188969
http://dx.doi.org/10.1093/aje/kwy185