Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation

Antifungal resistance due to upregulation of efflux pumps is prevalent in clinical Candida isolates. Potential efflux pump substrates (PEPSs), which are active against strains deficient in efflux pumps but inactive against wild-type strains, are usually missed in routine antifungal screening. Here w...

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Detalles Bibliográficos
Autores principales: Chang, Wenqiang, Liu, Jun, Zhang, Ming, Shi, Hongzhuo, Zheng, Sha, Jin, Xueyang, Gao, Yanhui, Wang, Shuqi, Ji, Aiguo, Lou, Hongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269435/
https://www.ncbi.nlm.nih.gov/pubmed/30504815
http://dx.doi.org/10.1038/s41467-018-07633-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269435/
https://www.ncbi.nlm.nih.gov/pubmed/30504815
http://dx.doi.org/10.1038/s41467-018-07633-9

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