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Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
Dysregulation of Ca(2+)/calmodulin-dependent protein kinase (CaMK)II is closely linked with myocardial hypertrophy and heart failure. However, the mechanisms that regulate CaMKII activity are incompletely understood. Here we show that protein arginine methyltransferase 1 (PRMT1) is essential for pre...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269446/ https://www.ncbi.nlm.nih.gov/pubmed/30504773 http://dx.doi.org/10.1038/s41467-018-07606-y |