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Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB
Rifampicin resistance (Rif(R)) is caused by mutations in rpoB, encoding the β-subunit of RNA polymerase. Rif(R) mutations generally incur a fitness cost and in resistant isolates are frequently accompanied by compensatory mutations in rpoA, rpoB or rpoC. Previous studies of fitness compensation focu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269455/ https://www.ncbi.nlm.nih.gov/pubmed/30504835 http://dx.doi.org/10.1038/s41598-018-36005-y |