Cargando…

Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB

Rifampicin resistance (Rif(R)) is caused by mutations in rpoB, encoding the β-subunit of RNA polymerase. Rif(R) mutations generally incur a fitness cost and in resistant isolates are frequently accompanied by compensatory mutations in rpoA, rpoB or rpoC. Previous studies of fitness compensation focu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brandis, Gerrit, Hughes, Diarmaid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269455/ https://www.ncbi.nlm.nih.gov/pubmed/30504835 http://dx.doi.org/10.1038/s41598-018-36005-y

Ejemplares similares

Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution
por: Hughes, Diarmaid, et al.
Publicado: (2013)

HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis
por: Loiseau, Chloé, et al.
Publicado: (2020)

Rifampicin Resistance Associated with rpoB Mutations in Neisseria gonorrhoeae Clinical Strains Isolated in Austria, 2016 to 2020
por: Schaeffer, Justine, et al.
Publicado: (2022)

Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region
por: Ma, Pengjiao, et al.
Publicado: (2021)

Rifampicin-Resistance Mutations in the rpoB Gene in Bacillus velezensis CC09 have Pleiotropic Effects
por: Cai, Xun-Chao, et al.
Publicado: (2017)

rpoB mutations conferring rifampicin-resistance affect growth, stress response and motility in Vibrio vulnificus
por: Cutugno, Laura, et al.
Publicado: (2020)

The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding
por: Amusengeri, Arnold, et al.
Publicado: (2022)

Borderline rpoB mutations transmit at the same rate as common rpoB mutations in a tuberculosis cohort in Bangladesh
por: Lempens, Pauline, et al.
Publicado: (2023)

A Glutamine Insertion at Codon 432 of RpoB Confers Rifampicin Resistance in Mycobacterium tuberculosis
por: Lai, Li-Yin, et al.
Publicado: (2020)

Variable ability of rapid tests to detect Mycobacterium tuberculosis rpoB mutations conferring phenotypically occult rifampicin resistance
por: Torrea, Gabriela, et al.
Publicado: (2019)

Status of rpoB gene mutation associated with rifampicin-resistant Mycobacterium tuberculosis isolated in a rural setting in Nepal
por: Adhikari, Saroj, et al.
Publicado: (2021)

Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility
por: Patel, Yesha, et al.
Publicado: (2023)

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
por: Praski Alzrigat, Lisa, et al.
Publicado: (2017)

Reevaluating Rifampicin Breakpoint Concentrations for Mycobacterium tuberculosis Isolates with Disputed rpoB Mutations and Discordant Susceptibility Phenotypes
por: Wang, Wei, et al.
Publicado: (2022)

rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis
por: Li, Ma-chao, et al.
Publicado: (2021)

Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
por: Zhu, Jun-Hao, et al.
Publicado: (2018)

Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic
por: Isakova, Jainagul, et al.
Publicado: (2018)

Alterations in the Spectrum of Spontaneous Rifampicin-Resistance Mutations in the Bacillus subtilis rpoB Gene after Cultivation in the Human Spaceflight Environment
por: Fajardo-Cavazos, Patricia, et al.
Publicado: (2018)

Rifampicin‐resistant RpoB S522L Vibrio vulnificus exhibits disturbed stress response and hypervirulence traits
por: Cutugno, Laura, et al.
Publicado: (2023)

Variations in the occurrence of specific rpoB mutations in rifampicin-resistant Mycobacterium tuberculosis isolates from patients of different ethnic groups in Kuwait
por: Ahmad, Suhail, et al.
Publicado: (2012)

Cultivation of Staphylococcus epidermidis in the Human Spaceflight Environment Leads to Alterations in the Frequency and Spectrum of Spontaneous Rifampicin-Resistance Mutations in the rpoB Gene
por: Fajardo-Cavazos, Patricia, et al.
Publicado: (2016)

rpoB Mutations Causing Discordant Rifampicin Susceptibility in Mycobacterium tuberculosis: Retrospective Analysis of Prevalence, Phenotypic, Genotypic, and Treatment Outcomes
por: Mvelase, Nomonde R, et al.
Publicado: (2019)

Characterization of the impact of rpoB mutations on the in vitro and in vivo competitive fitness of Clostridium difficile and susceptibility to fidaxomicin
por: Kuehne, Sarah A, et al.
Publicado: (2018)

Detection of Mycobacterium tuberculosis Rifampicin Resistance Conferred by Borderline rpoB Mutations: Xpert MTB/RIF is Superior to Phenotypic Drug Susceptibility Testing
por: Xia, Hui, et al.
Publicado: (2022)

Drug resistance and the genotypic characteristics of rpoB and katG in rifampicin- and/or isoniazid-resistant Mycobacterium tuberculosis isolates in central Vietnam
por: Nguyen, Thi Binh Nguyen, et al.
Publicado: (2023)

Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis
por: Xu, Zhihong, et al.
Publicado: (2018)

Escherichia coli rpoB Mutants Have Increased Evolvability in Proportion to Their Fitness Defects
por: Barrick, Jeffrey E., et al.
Publicado: (2010)

Detection of Mycobacterium tuberculosis in extrapulmonary biopsy samples using PCR targeting IS6110, rpoB, and nested-rpoB PCR Cloning
por: Meghdadi, Hossein, et al.
Publicado: (2015)

Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin
por: Zaczek, Anna, et al.
Publicado: (2009)

Rifabutin Resistance Associated with Double Mutations in rpoB Gene in Mycobacterium tuberculosis Isolates
por: Jing, Wei, et al.
Publicado: (2017)

rpoB Mutations are Associated with Variable Levels of Rifampin and Rifabutin Resistance in Mycobacterium tuberculosis
por: Li, Ma-Chao, et al.
Publicado: (2022)

Mutation of rpoB Shifts the Nutrient Threshold Triggering Myxococcus Multicellular Development
por: Eisner, Sabrina A., et al.
Publicado: (2022)

An in silico analysis of rpoB mutations to affect Chlamydia trachomatis sensitivity to rifamycin
por: Benamri, Ichrak, et al.
Publicado: (2022)

Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of multidrug-resistant tuberculosis
por: Al-Mutairi, Noura M., et al.
Publicado: (2019)

Distribution and Frequency of rpoB Mutations Detected by Xpert MTB/RIF Assay Among Beijing and Non-Beijing Rifampicin Resistant Mycobacterium tuberculosis Isolates in Bangladesh
por: Uddin, Mohammad Khaja Mafij, et al.
Publicado: (2020)

Mycobacterium tuberculosis carrying the rifampicin drug-resistance-conferring rpoB mutation H445Y is associated with suppressed immunity through type I interferons
por: Bobba, Suhas, et al.
Publicado: (2023)

Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli
por: Huseby, Douglas L., et al.
Publicado: (2017)

Detection of mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains inhibiting wild type probe hybridization in the MTBDR plus assay by DNA sequencing directly from clinical specimens
por: Sinha, Pallavi, et al.
Publicado: (2020)

Commentary: Rifabutin Resistance Associated with Double Mutations in rpoB Gene in Mycobacterium tuberculosis Isolates
por: Sharma, Sandeep, et al.
Publicado: (2017)

Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf
por: Hua, Xiaoting, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_le1dma8vfn2iq3srmaadp4mr50