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Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB

Rifampicin resistance (Rif(R)) is caused by mutations in rpoB, encoding the β-subunit of RNA polymerase. Rif(R) mutations generally incur a fitness cost and in resistant isolates are frequently accompanied by compensatory mutations in rpoA, rpoB or rpoC. Previous studies of fitness compensation focu...

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Detalles Bibliográficos
Autores principales:	Brandis, Gerrit, Hughes, Diarmaid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269455/ https://www.ncbi.nlm.nih.gov/pubmed/30504835 http://dx.doi.org/10.1038/s41598-018-36005-y

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