Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours

Tumours often evade CD8 T-cell immunity by downregulating TAP. T-cell epitopes associated with impaired peptide processing are immunogenic non-mutated neoantigens that emerge during tumour immune evasion. The preprocalcitonin (ppCT)(16–25) neoepitope belongs to this category of antigens. Here we sho...

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Detalles Bibliográficos
Autores principales: Durgeau, Aurélie, Virk, Yasemin, Gros, Gwendoline, Voilin, Elodie, Corgnac, Stéphanie, Djenidi, Fayçal, Salmon, Jérôme, Adam, Julien, de Montpréville, Vincent, Validire, Pierre, Ferrone, Soldano, Chouaib, Salem, Eggermont, Alexander, Soria, Jean-Charles, Lemonnier, François, Tartour, Eric, Chaput, Nathalie, Besse, Benjamin, Mami-Chouaib, Fathia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269466/
https://www.ncbi.nlm.nih.gov/pubmed/30504837
http://dx.doi.org/10.1038/s41467-018-07603-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269466/
https://www.ncbi.nlm.nih.gov/pubmed/30504837
http://dx.doi.org/10.1038/s41467-018-07603-1

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