In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors

Chemotherapy resistance is responsible for high mortality rates in neuroblastoma. MYCN, an oncogenic driver in neuroblastoma, controls pluripotency genes including LIN28B. We hypothesized that enhanced embryonic stem cell (ESC) gene regulatory programs could mark tumors with high pluripotency capaci...

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Detalles Bibliográficos
Autores principales: Vanhauwaert, Suzanne, Decaesteker, Bieke, De Brouwer, Sara, Leonelli, Carina, Durinck, Kaat, Mestdagh, Pieter, Vandesompele, Jo, Sermon, Karen, Denecker, Geertrui, Van Neste, Christophe, Speleman, Frank, De Preter, Katleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269481/
https://www.ncbi.nlm.nih.gov/pubmed/30504901
http://dx.doi.org/10.1038/s41598-018-35868-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269481/
https://www.ncbi.nlm.nih.gov/pubmed/30504901
http://dx.doi.org/10.1038/s41598-018-35868-5

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