Bortezomib Congeners Induce Apoptosis of Hepatocellular Carcinoma via CIP2A Inhibition

CIP2A is an oncoprotein that upregulates p-Akt and promotes cancer cell proliferation and survival. The proteasome inhibitor bortezomib has been shown to reduce CIP2A and lead to cell apoptosis. Here; we modified the functional group of bortezomib to generate a series of novel compounds and conducte...

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Detalles Bibliográficos
Autores principales: Hou, Duen-Ren, Huang, Ann-Chi, Shiau, Chung-Wai, Wang, Chun-Yi, Yu, Hui-Chuan, Chen, Kuen-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269665/
https://www.ncbi.nlm.nih.gov/pubmed/24335617
http://dx.doi.org/10.3390/molecules181215398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269665/
https://www.ncbi.nlm.nih.gov/pubmed/24335617
http://dx.doi.org/10.3390/molecules181215398

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