General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products

Protected L-homoDMDP en-8 and its C-6 epimer en-7 were prepared through two different pathways starting from the vinylpyrrolidine en-9. Based on the NMR and X-ray analysis, the stereochemistry of homoDMDP at C-6 was confirmed to be consistent with reported data. Compounds en-7 and en-8 are general i...

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Autores principales: Huang, Mu-Hua, Li, Yi-Xian, Jia, Yue-Mei, Yu, Chu-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269708/
https://www.ncbi.nlm.nih.gov/pubmed/23749160
http://dx.doi.org/10.3390/molecules18066723
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author Huang, Mu-Hua
Li, Yi-Xian
Jia, Yue-Mei
Yu, Chu-Yi
author_facet Huang, Mu-Hua
Li, Yi-Xian
Jia, Yue-Mei
Yu, Chu-Yi
author_sort Huang, Mu-Hua
collection PubMed
description Protected L-homoDMDP en-8 and its C-6 epimer en-7 were prepared through two different pathways starting from the vinylpyrrolidine en-9. Based on the NMR and X-ray analysis, the stereochemistry of homoDMDP at C-6 was confirmed to be consistent with reported data. Compounds en-7 and en-8 are general intermediates for the synthesis of a series of 6-C-alkylated DMDP-related natural products, such as broussonetine G, homoDMDP-7-O-apioside, homoDMDP-7-O-β-D-xyloside and so on.
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spelling pubmed-62697082018-12-17 General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products Huang, Mu-Hua Li, Yi-Xian Jia, Yue-Mei Yu, Chu-Yi Molecules Article Protected L-homoDMDP en-8 and its C-6 epimer en-7 were prepared through two different pathways starting from the vinylpyrrolidine en-9. Based on the NMR and X-ray analysis, the stereochemistry of homoDMDP at C-6 was confirmed to be consistent with reported data. Compounds en-7 and en-8 are general intermediates for the synthesis of a series of 6-C-alkylated DMDP-related natural products, such as broussonetine G, homoDMDP-7-O-apioside, homoDMDP-7-O-β-D-xyloside and so on. MDPI 2013-06-06 /pmc/articles/PMC6269708/ /pubmed/23749160 http://dx.doi.org/10.3390/molecules18066723 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Mu-Hua
Li, Yi-Xian
Jia, Yue-Mei
Yu, Chu-Yi
General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products
title General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products
title_full General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products
title_fullStr General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products
title_full_unstemmed General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products
title_short General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products
title_sort general intermediates for the synthesis of 6-c-alkylated dmdp-related natural products
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269708/
https://www.ncbi.nlm.nih.gov/pubmed/23749160
http://dx.doi.org/10.3390/molecules18066723
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