Novel Conformationally Constrained Analogues of Agomelatine as New Melatoninergic Ligands

Novel conformationally restricted analogues of agomelatine were synthesized and pharmacologically evaluated at MT(1) and MT(2) melatoninergic receptors. Replacement of the N-acetyl side chain of agomelatine by oxathiadiazole-2-oxide (compound 3), oxadiazole-5(4H)-one (compound 4), tetrazole (compoun...

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Detalles Bibliográficos
Autores principales: Rami, Marouan, Landagaray, Elodie, Ettaoussi, Mohamed, Boukhalfa, Koussayla, Caignard, Daniel-Henri, Delagrange, Philippe, Berthelot, Pascal, Yous, Saïd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269769/
https://www.ncbi.nlm.nih.gov/pubmed/23262445
http://dx.doi.org/10.3390/molecules18010154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269769/
https://www.ncbi.nlm.nih.gov/pubmed/23262445
http://dx.doi.org/10.3390/molecules18010154

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