Discovery of Hybrid Dual N-Acylhydrazone and Diaryl Urea Derivatives as Potent Antitumor Agents: Design, Synthesis and Cytotoxicity Evaluation

Based on the hybrid pharmacophore design concept, a novel series of dual diaryl urea and N-acylhydrazone derivatives were synthesized and evaluated for their in vitro cytotoxicity by the standard MTT assay. The pharmacological results indicated that most compounds exhibited moderate to excellent act...

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Detalles Bibliográficos
Autores principales: Zhai, Xin, Huang, Qiang, Jiang, Nan, Wu, Di, Zhou, Hongyu, Gong, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269785/
https://www.ncbi.nlm.nih.gov/pubmed/23459301
http://dx.doi.org/10.3390/molecules18032904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269785/
https://www.ncbi.nlm.nih.gov/pubmed/23459301
http://dx.doi.org/10.3390/molecules18032904

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