Cargando…

Discovery of Hybrid Dual N-Acylhydrazone and Diaryl Urea Derivatives as Potent Antitumor Agents: Design, Synthesis and Cytotoxicity Evaluation

Based on the hybrid pharmacophore design concept, a novel series of dual diaryl urea and N-acylhydrazone derivatives were synthesized and evaluated for their in vitro cytotoxicity by the standard MTT assay. The pharmacological results indicated that most compounds exhibited moderate to excellent act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhai, Xin, Huang, Qiang, Jiang, Nan, Wu, Di, Zhou, Hongyu, Gong, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269785/ https://www.ncbi.nlm.nih.gov/pubmed/23459301 http://dx.doi.org/10.3390/molecules18032904

Ejemplares similares

Diarylation of thiazolopyrimidines by laccase and their in vitro evaluation as antitumor agents
por: Shahedi, Mansour, et al.
Publicado: (2022)

Discovery of a Novel Hybrid of Vorinostat and Riluzole as a Potent Antitumor Agent
por: Xu, Qifu, et al.
Publicado: (2020)

Drug repurposing: Discovery of troxipide analogs as potent antitumor agents
por: Lu, Nan, et al.
Publicado: (2020)

Design, Synthesis and Structure-Activity Relationships of Novel Diaryl Urea Derivatives as Potential EGFR Inhibitors
por: Jiang, Nan, et al.
Publicado: (2016)

Design, Synthesis and Biological Evaluation of Novel Substituted N,N′-Diaryl ureas as Potent p38 Inhibitors
por: Zhu, Dianxi, et al.
Publicado: (2015)

Discovery of Novel Quinazoline Derivatives as Potent Antitumor Agents
por: Niu, Zhenxi, et al.
Publicado: (2022)

Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
por: Osmaniye, Derya, et al.
Publicado: (2018)

Trifluoromethylated hydrazones and acylhydrazones as potent nitrogen-containing fluorinated building blocks
por: Dongxu, Zhang
Publicado: (2023)

Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids
por: Lazzarini, Cristina, et al.
Publicado: (2018)

Hybrids of Sterically Hindered Phenols and Diaryl Ureas: Synthesis, Switch from Antioxidant Activity to ROS Generation and Induction of Apoptosis
por: Gibadullina, Elmira, et al.
Publicado: (2023)

Synthesis and characterization of some novel diaryl urea derivatives bearing quinoxalindione moiety
por: Sadeghian-Rizi, Sedighe, et al.
Publicado: (2018)

Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents
por: Hura, Neha, et al.
Publicado: (2018)

Evaluation of antioxidant and cytotoxic properties of phenolic N-acylhydrazones: structure–activity relationship
por: Branković, Jovica, et al.
Publicado: (2022)

Some novel hybrid quinazoline-based heterocycles as potent cytotoxic agents
por: Malekzadeh, Mahla, et al.
Publicado: (2021)

Cytotoxic Mechanisms of FK317, a New Class of Bioreductive Agent with Potent Antitumor Activity
por: Naoe, Yoshinori, et al.
Publicado: (1998)

Hydroxide-Mediated S(N)Ar Rearrangement for Synthesis of Novel Depside Derivatives Containing Diaryl Ether Skeleton as Antitumor Agents
por: Yu, Xiang, et al.
Publicado: (2023)

Acylhydrazones and Their Biological Activity: A Review
por: Socea, Laura-Ileana, et al.
Publicado: (2022)

Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease
por: de Freitas Silva, Matheus, et al.
Publicado: (2020)

A quantitative structure-activity relationship (QSAR) study of some diaryl urea derivatives of B-RAF inhibitors
por: Sadeghian-Rizi, Sedighe, et al.
Publicado: (2016)

Biological evaluation, docking and molecular dynamic simulation of some novel diaryl urea derivatives bearing quinoxalindione moiety
por: Sadeghian-Rizi, Sedighe, et al.
Publicado: (2017)

Photoinduced synthesis of unsymmetrical diaryl selenides from triarylbismuthines and diaryl diselenides
por: Kobiki, Yohsuke, et al.
Publicado: (2013)

Synthesis, Structural Characterization, and Cytotoxic Activity of Novel Paramagnetic Platinum Hematoporphyrin IX Complexes: Potent Antitumor Agents
por: Gencheva, G., et al.
Publicado: (2007)

Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease
por: Jiang, Xiaoying, et al.
Publicado: (2021)

Vicinal Diaryl-Substituted Isoxazole and Pyrazole Derivatives with In Vitro Growth Inhibitory and In Vivo Antitumor Activity
por: Turanlı, Sümeyye, et al.
Publicado: (2022)

Homocouplings of Sodium Arenesulfinates: Selective Access to Symmetric Diaryl Sulfides and Diaryl Disulfides
por: Yu, Xin-Zhang, et al.
Publicado: (2022)

Discovery of the First N-Hydroxycinnamamide-Based Histone Deacetylase 1/3 Dual Inhibitors with Potent Oral Antitumor Activity
por: Li, Xiaoyang, et al.
Publicado: (2014)

Diaryl Urea Derivative Molecule Inhibits Cariogenic Streptococcus mutans by Affecting Exopolysaccharide Synthesis, Stress Response, and Nitrogen Metabolism
por: Liao, Ying, et al.
Publicado: (2022)

Diaryl ethers with carboxymethoxyphenacyl motif as potent HIV-1 reverse transcriptase inhibitors with improved solubility
por: Frączek, Tomasz, et al.
Publicado: (2017)

Synthesis, Docking and Biological Activities of Novel Hybrids Celecoxib and Anthraquinone Analogs as Potent Cytotoxic Agents
por: Almutairi, Maha S., et al.
Publicado: (2014)

Identification of a strong and specific antichlamydial N-acylhydrazone
por: Zhang, Huirong, et al.
Publicado: (2017)

Antiprotozoal Activity of (E)-Cinnamic N-Acylhydrazone Derivatives
por: Carvalho, Samir Aquino, et al.
Publicado: (2014)

Crystal structures of three N-acylhydrazone isomers
por: Purandara, H., et al.
Publicado: (2021)

Discovery of a potent olaparib–chlorambucil hybrid inhibitor of PARP1 for the treatment of cancer
por: Qin, Hongyu, et al.
Publicado: (2023)

Discovery of Indeno[1,2-c]quinoline Derivatives as Potent Dual Antituberculosis and Anti-Inflammatory Agents
por: Tseng, Chih-Hua, et al.
Publicado: (2017)

Design, synthesis, and cytotoxicity evaluation of novel indole-acylhydrazone derivatives of 4-pyridinone as potential histone deacetylase-2 inhibitors
por: Naghi-Ganji, Niloofar, et al.
Publicado: (2022)

Potent Antitumor Activity Generated by a Novel Tumor Specific Cytotoxic T Cell
por: Wang, Zheng, et al.
Publicado: (2013)

Design, synthesis and evaluation of novel tetrahydropyridothienopyrimidin-ureas as cytotoxic and anti-angiogenic agents
por: Motahari, Rasoul, et al.
Publicado: (2022)

NFBTA: A Potent Cytotoxic Agent against Glioblastoma
por: Turkez, Hasan, et al.
Publicado: (2019)

A Novel Series of Acylhydrazones as Potential Anti-Candida Agents: Design, Synthesis, Biological Evaluation and In Silico Studies
por: Borcea, Anca-Maria, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of Benzo[b]thiophene Acylhydrazones as Antimicrobial Agents against Multidrug-Resistant Staphylococcus aureus
por: Barbier, Thibaut, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m0dklum246516jpo79ftmepq3s