The Effect of Conformational Variability of Phosphotriesterase upon N-acyl-L-homoserine Lactone and Paraoxon Binding: Insights from Molecular Dynamics Studies

The organophosphorous hydrolase (PTE) from Brevundimonas diminuta is capable of degrading extremely toxic organophosphorous compounds with a high catalytic turnover and broad substrate specificity. Although the natural substrate for PTE is unknown, its loop remodeling (loop 7-2/H254R) led to the eme...

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Detalles Bibliográficos
Autores principales: Zhan, Dongling, Zhou, Zhenhuan, Guan, Shanshan, Han, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269825/
https://www.ncbi.nlm.nih.gov/pubmed/24352010
http://dx.doi.org/10.3390/molecules181215501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269825/
https://www.ncbi.nlm.nih.gov/pubmed/24352010
http://dx.doi.org/10.3390/molecules181215501

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