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Solid Phase versus Solution Phase Synthesis of Heterocyclic Macrocycles
Comparing a solution phase route to a solid phase route in the synthesis of the cytotoxic natural product urukthapelstatin A (Ustat A) confirmed that a solid phase method is superior. The solution phase approach was tedious and involved cyclization of a ridged heterocyclic precursor, while solid pha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269862/ https://www.ncbi.nlm.nih.gov/pubmed/23325099 http://dx.doi.org/10.3390/molecules18011111 |