Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents

In order to find novel antiviral agents, a series of allosteric MEK1 inhibitors were designed and synthesized. Based on docking results, multiple optimizations were made on the coumarin scaffold. Some of the derivatives showed excellent MEK1 binding affinity in the appropriate enzymatic assays and d...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Zhang, Hao, Xu, Fengrong, Niu, Yan, Wu, Yun, Wang, Xin, Peng, Yihong, Sun, Jing, Liang, Lei, Xu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269873/
https://www.ncbi.nlm.nih.gov/pubmed/23698055
http://dx.doi.org/10.3390/molecules18056057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269873/
https://www.ncbi.nlm.nih.gov/pubmed/23698055
http://dx.doi.org/10.3390/molecules18056057

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