Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16

A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackie...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xian, Wang, Hongliang, Li, Yuhuan, Cao, Ruiyuan, Zhong, Wu, Zheng, Zhibing, Wang, Gang, Xiao, Junhai, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269887/
https://www.ncbi.nlm.nih.gov/pubmed/23629759
http://dx.doi.org/10.3390/molecules18055059
_version_ 1783376571583692800
author Zhang, Xian
Wang, Hongliang
Li, Yuhuan
Cao, Ruiyuan
Zhong, Wu
Zheng, Zhibing
Wang, Gang
Xiao, Junhai
Li, Song
author_facet Zhang, Xian
Wang, Hongliang
Li, Yuhuan
Cao, Ruiyuan
Zhong, Wu
Zheng, Zhibing
Wang, Gang
Xiao, Junhai
Li, Song
author_sort Zhang, Xian
collection PubMed
description A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.
format Online
Article
Text
id pubmed-6269887
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62698872018-12-14 Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16 Zhang, Xian Wang, Hongliang Li, Yuhuan Cao, Ruiyuan Zhong, Wu Zheng, Zhibing Wang, Gang Xiao, Junhai Li, Song Molecules Article A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity. MDPI 2013-04-29 /pmc/articles/PMC6269887/ /pubmed/23629759 http://dx.doi.org/10.3390/molecules18055059 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhang, Xian
Wang, Hongliang
Li, Yuhuan
Cao, Ruiyuan
Zhong, Wu
Zheng, Zhibing
Wang, Gang
Xiao, Junhai
Li, Song
Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16
title Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16
title_full Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16
title_fullStr Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16
title_full_unstemmed Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16
title_short Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16
title_sort novel substituted heteroaromatic piperazine and piperidine derivatives as inhibitors of human enterovirus 71 and coxsackievirus a16
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269887/
https://www.ncbi.nlm.nih.gov/pubmed/23629759
http://dx.doi.org/10.3390/molecules18055059
work_keys_str_mv AT zhangxian novelsubstitutedheteroaromaticpiperazineandpiperidinederivativesasinhibitorsofhumanenterovirus71andcoxsackievirusa16
AT wanghongliang novelsubstitutedheteroaromaticpiperazineandpiperidinederivativesasinhibitorsofhumanenterovirus71andcoxsackievirusa16
AT liyuhuan novelsubstitutedheteroaromaticpiperazineandpiperidinederivativesasinhibitorsofhumanenterovirus71andcoxsackievirusa16
AT caoruiyuan novelsubstitutedheteroaromaticpiperazineandpiperidinederivativesasinhibitorsofhumanenterovirus71andcoxsackievirusa16
AT zhongwu novelsubstitutedheteroaromaticpiperazineandpiperidinederivativesasinhibitorsofhumanenterovirus71andcoxsackievirusa16
AT zhengzhibing novelsubstitutedheteroaromaticpiperazineandpiperidinederivativesasinhibitorsofhumanenterovirus71andcoxsackievirusa16
AT wanggang novelsubstitutedheteroaromaticpiperazineandpiperidinederivativesasinhibitorsofhumanenterovirus71andcoxsackievirusa16
AT xiaojunhai novelsubstitutedheteroaromaticpiperazineandpiperidinederivativesasinhibitorsofhumanenterovirus71andcoxsackievirusa16
AT lisong novelsubstitutedheteroaromaticpiperazineandpiperidinederivativesasinhibitorsofhumanenterovirus71andcoxsackievirusa16

Ejemplares similares