Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand

Macrocyclic hexaoxazole dimer of L2H2-6OTD-dimer (3) was newly synthesized as a telomeric G-quadruplex (G4) ligand, and interaction with long telomeric DNAs telo48, 72, and 96 was evaluated by means of electrophoresis mobility shift assay, CD spectra analysis, and CD melting experiments. The L2H2-6O...

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Detalles Bibliográficos
Autores principales: Iida, Keisuke, Majima, Satoki, Nakamura, Takahiro, Seimiya, Hiroyuki, Nagasawa, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269967/
https://www.ncbi.nlm.nih.gov/pubmed/23584054
http://dx.doi.org/10.3390/molecules18044328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269967/
https://www.ncbi.nlm.nih.gov/pubmed/23584054
http://dx.doi.org/10.3390/molecules18044328

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