Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose

The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesi...

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Autores principales: D’Errico, Stefano, Oliviero, Giorgia, Borbone, Nicola, Amato, Jussara, Piccialli, Vincenzo, Varra, Michela, Mayol, Luciano, Piccialli, Gennaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269997/
https://www.ncbi.nlm.nih.gov/pubmed/23924994
http://dx.doi.org/10.3390/molecules18089420
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author D’Errico, Stefano
Oliviero, Giorgia
Borbone, Nicola
Amato, Jussara
Piccialli, Vincenzo
Varra, Michela
Mayol, Luciano
Piccialli, Gennaro
author_facet D’Errico, Stefano
Oliviero, Giorgia
Borbone, Nicola
Amato, Jussara
Piccialli, Vincenzo
Varra, Michela
Mayol, Luciano
Piccialli, Gennaro
author_sort D’Errico, Stefano
collection PubMed
description The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a d-ribityl or by a hydroxybutyl chain.
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spelling pubmed-62699972018-12-18 Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose D’Errico, Stefano Oliviero, Giorgia Borbone, Nicola Amato, Jussara Piccialli, Vincenzo Varra, Michela Mayol, Luciano Piccialli, Gennaro Molecules Article The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a d-ribityl or by a hydroxybutyl chain. MDPI 2013-08-06 /pmc/articles/PMC6269997/ /pubmed/23924994 http://dx.doi.org/10.3390/molecules18089420 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
D’Errico, Stefano
Oliviero, Giorgia
Borbone, Nicola
Amato, Jussara
Piccialli, Vincenzo
Varra, Michela
Mayol, Luciano
Piccialli, Gennaro
Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
title Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
title_full Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
title_fullStr Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
title_full_unstemmed Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
title_short Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
title_sort synthesis of new acadesine (aica-riboside) analogues having acyclic d-ribityl or 4-hydroxybutyl chains in place of the ribose
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269997/
https://www.ncbi.nlm.nih.gov/pubmed/23924994
http://dx.doi.org/10.3390/molecules18089420
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