Inhibitory Evaluation of Sulfonamide Chalcones on β-Secretase and Acylcholinesterase

The action of β-secretase (BACE1) is strongly correlated with the onset of Alzheimer’s disease (AD). Aminochalcone derivatives were examined for their ability to inhibit BACE1. Parent aminochalcones showed two digit micromolar IC(50)s against BACE1. Potency was enhanced 10-fold or more by introducin...

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Detalles Bibliográficos
Autores principales: Kang, Jae Eun, Cho, Jung Keun, Curtis-Long, Marcus J., Ryu, Hyung Won, Kim, Jin Hyo, Kim, Hye Jin, Yuk, Heung Joo, Kim, Dae Wook, Park, Ki Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270012/
https://www.ncbi.nlm.nih.gov/pubmed/23344193
http://dx.doi.org/10.3390/molecules18010140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270012/
https://www.ncbi.nlm.nih.gov/pubmed/23344193
http://dx.doi.org/10.3390/molecules18010140

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