Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent β-secretase (BACE1) Inhibitors

Proteolytic cleavage of amyloid precursor protein by β-secretase (BACE1) is a key step in generating the N-terminal of β-amyloid (Aβ), which further forms into amyloid plaques that are considered as the hallmark of Alzheimer’s disease. Inhibitors of BACE1 can reduce the levels of Aβ and thus have a...

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Detalles Bibliográficos
Autores principales: Zou, Yiquan, Li, Li, Chen, Wuyan, Chen, Tiantian, Ma, Lanping, Wang, Xin, Xiong, Bing, Xu, Yechun, Shen, Jingkang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270065/
https://www.ncbi.nlm.nih.gov/pubmed/23681056
http://dx.doi.org/10.3390/molecules18055706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270065/
https://www.ncbi.nlm.nih.gov/pubmed/23681056
http://dx.doi.org/10.3390/molecules18055706

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