Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries

The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% w...

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Detalles Bibliográficos
Autores principales: Roy, Subhadeep, Caruthers, Marvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270087/
https://www.ncbi.nlm.nih.gov/pubmed/24252996
http://dx.doi.org/10.3390/molecules181114268
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author Roy, Subhadeep
Caruthers, Marvin
author_facet Roy, Subhadeep
Caruthers, Marvin
author_sort Roy, Subhadeep
collection PubMed
description The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% with very few side products. Additionally the synthesis and properties of certain DNA and RNA analogs that are modified at phosphorus will also be discussed. These analogs include boranephosphonates, metallophosphonates, and alkylboranephosphines.
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spelling pubmed-62700872018-12-20 Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries Roy, Subhadeep Caruthers, Marvin Molecules Review The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% with very few side products. Additionally the synthesis and properties of certain DNA and RNA analogs that are modified at phosphorus will also be discussed. These analogs include boranephosphonates, metallophosphonates, and alkylboranephosphines. MDPI 2013-11-18 /pmc/articles/PMC6270087/ /pubmed/24252996 http://dx.doi.org/10.3390/molecules181114268 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Roy, Subhadeep
Caruthers, Marvin
Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
title Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
title_full Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
title_fullStr Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
title_full_unstemmed Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
title_short Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
title_sort synthesis of dna/rna and their analogs via phosphoramidite and h-phosphonate chemistries
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270087/
https://www.ncbi.nlm.nih.gov/pubmed/24252996
http://dx.doi.org/10.3390/molecules181114268
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