Pd(0)-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer

The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under “ligandless” conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even un...

Descripción completa

Detalles Bibliográficos
Autores principales: James, Damien, Escudier, Jean-Marc, Szlosek-Pinaud, Magali, Fouquet, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270090/
https://www.ncbi.nlm.nih.gov/pubmed/24196412
http://dx.doi.org/10.3390/molecules181113654
_version_ 1783376617802825728
author James, Damien
Escudier, Jean-Marc
Szlosek-Pinaud, Magali
Fouquet, Eric
author_facet James, Damien
Escudier, Jean-Marc
Szlosek-Pinaud, Magali
Fouquet, Eric
author_sort James, Damien
collection PubMed
description The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under “ligandless” conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11.
format Online
Article
Text
id pubmed-6270090
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62700902018-12-20 Pd(0)-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer James, Damien Escudier, Jean-Marc Szlosek-Pinaud, Magali Fouquet, Eric Molecules Article The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under “ligandless” conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11. MDPI 2013-11-05 /pmc/articles/PMC6270090/ /pubmed/24196412 http://dx.doi.org/10.3390/molecules181113654 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
James, Damien
Escudier, Jean-Marc
Szlosek-Pinaud, Magali
Fouquet, Eric
Pd(0)-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer
title Pd(0)-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer
title_full Pd(0)-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer
title_fullStr Pd(0)-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer
title_full_unstemmed Pd(0)-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer
title_short Pd(0)-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer
title_sort pd(0)-catalyzed methyl transfer on nucleosides and oligonucleotides, envisaged as a pet tracer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270090/
https://www.ncbi.nlm.nih.gov/pubmed/24196412
http://dx.doi.org/10.3390/molecules181113654
work_keys_str_mv AT jamesdamien pd0catalyzedmethyltransferonnucleosidesandoligonucleotidesenvisagedasapettracer
AT escudierjeanmarc pd0catalyzedmethyltransferonnucleosidesandoligonucleotidesenvisagedasapettracer
AT szlosekpinaudmagali pd0catalyzedmethyltransferonnucleosidesandoligonucleotidesenvisagedasapettracer
AT fouqueteric pd0catalyzedmethyltransferonnucleosidesandoligonucleotidesenvisagedasapettracer

Ejemplares similares