Synthesis, Biological Evaluation, and Pharmacokinetic Study of Novel Liguzinediol Prodrugs

Liguzinediol (LZDO) ester prodrugs 3–5 were synthesized and evaluated in vitro and in vivo for their potential use in prolonging the half-life of the parent drug LZDO (1a) in vivo. Prodrugs 3–5 were found to display a potent positive inotropic effect on the myocardium, without the risk of arrhythmia...

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Detalles Bibliográficos
Autores principales: Liu, Zheng, Li, Wei, Wen, Hong-Mei, Bian, Hui-Min, Zhang, Jing, Chen, Lei, Chen, Long, Yang, Kun-Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270099/
https://www.ncbi.nlm.nih.gov/pubmed/23599014
http://dx.doi.org/10.3390/molecules18044561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270099/
https://www.ncbi.nlm.nih.gov/pubmed/23599014
http://dx.doi.org/10.3390/molecules18044561

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