Cargando…

Synthesis, Biological Evaluation, and Pharmacokinetic Study of Novel Liguzinediol Prodrugs

Liguzinediol (LZDO) ester prodrugs 3–5 were synthesized and evaluated in vitro and in vivo for their potential use in prolonging the half-life of the parent drug LZDO (1a) in vivo. Prodrugs 3–5 were found to display a potent positive inotropic effect on the myocardium, without the risk of arrhythmia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zheng, Li, Wei, Wen, Hong-Mei, Bian, Hui-Min, Zhang, Jing, Chen, Lei, Chen, Long, Yang, Kun-Di
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270099/ https://www.ncbi.nlm.nih.gov/pubmed/23599014 http://dx.doi.org/10.3390/molecules18044561

Ejemplares similares

Synthesis and Biological Evaluation of Liguzinediol Mono- and Dual Ester Prodrugs as Promising Inotropic Agents
por: Zhang, Jing, et al.
Publicado: (2014)

The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism
por: Chen, Qi, et al.
Publicado: (2020)

PSMA-Oriented Target Delivery of Novel Anticancer Prodrugs: Design, Synthesis, and Biological Evaluations of Oligopeptide-Camptothecin Conjugates
por: Xu, Bing, et al.
Publicado: (2018)

Synthesis, Biological Evaluation and Low-Toxic Formulation Development of Glycosylated Paclitaxel Prodrugs
por: Mao, Yukang, et al.
Publicado: (2018)

Understanding the pharmacokinetics of prodrug and metabolite
por: Cho, Seungil, et al.
Publicado: (2018)

Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs
por: Schooley, Robert T., et al.
Publicado: (2021)

Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs
por: Schooley, Robert T., et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Novel 10-Substituted-7-ethyl-10-hydroxycamptothecin (SN-38) Prodrugs
por: Zhou, Mo, et al.
Publicado: (2014)

A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential
por: Maccallini, Cristina, et al.
Publicado: (2020)

Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties
por: Hong, Sungwoo, et al.
Publicado: (2018)

Synthesis, Screening and Pharmacokinetic Evaluation of Potential Prodrugs of Bupropion. Part One: In Vitro Development
por: O’Byrne, Paul Matthew, et al.
Publicado: (2014)

Novel glycosyl prodrug of RXP03 as MMP-11 prodrug: design, synthesis and virtual screening
por: Abdou, Moaz M., et al.
Publicado: (2023)

Pharmacokinetic Study of a Novel Antihyperlipidemic Agent LM-13765- A Prodrug
por: Shah, T. M., et al.
Publicado: (2009)

Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides
por: McGuigan, Christopher, et al.
Publicado: (2013)

TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation
por: Laquintana, Valentino, et al.
Publicado: (2016)

Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs
por: Pileggi, Elisa, et al.
Publicado: (2018)

Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs
por: Liu, Hui, et al.
Publicado: (2016)

Spacer/Linker Based Synthesis and Biological Evaluation of Mutual Prodrugs as Antiinflammatory Agents
por: Velingkar, V. S., et al.
Publicado: (2010)

Synthesis, Characterization and Biological Evaluation of Succinate Prodrugs of Curcuminoids for Colon Cancer Treatment
por: Wichitnithad, Wisut, et al.
Publicado: (2011)

Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug
por: Wang, Jing-Hung, et al.
Publicado: (2016)

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine
por: Bakker, Charlotte, et al.
Publicado: (2020)

First-In-Human Study on Pharmacokinetics, Safety, and Tolerability of Single and Multiple Escalating Doses of Hepenofovir, a Novel Hepatic Targeting Prodrug of Tenofovir in Healthy Chinese Subjects
por: Zhang, Hong, et al.
Publicado: (2022)

Use of physiological based pharmacokinetic modeling for cross-species prediction of pharmacokinetic and tissue distribution profiles of a novel niclosamide prodrug
por: Yang, Mengbi, et al.
Publicado: (2023)

Pharmacokinetics and Abuse Potential of Benzhydrocodone, a Novel Prodrug of Hydrocodone, After Intranasal Administration in Recreational Drug Users
por: Mickle, Travis C, et al.
Publicado: (2018)

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents
por: Omran, Ziad, et al.
Publicado: (2021)

Pre-Clinical Pharmacokinetic Characterization, Tissue Distribution, and Excretion Studies of Novel Edaravone Oral Prodrug, TEJ-1704
por: Kang, Dong Wook, et al.
Publicado: (2021)

Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs
por: Pradere, Ugo, et al.
Publicado: (2014)

Synthesis and Biochemical Evaluation of Baicalein Prodrugs
por: Son, Sang-Hyun, et al.
Publicado: (2021)

Desymmetrization of pibrentasvir for efficient prodrug synthesis
por: Voight, Eric A., et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001
por: Xiao, Dian, et al.
Publicado: (2016)

Synthesis and Biological Evaluation of a Novel Pentagastrin-Toxin Conjugate Designed for a Targeted Prodrug Mono-therapy of Cancer
por: Tietze, Lutz F., et al.
Publicado: (2008)

Synthesis of a Novel Series of Amino Acid Prodrugs Based on Thienopyridine Scaffolds and Evaluation of Their Antiplatelet Activity
por: Lu, Nan, et al.
Publicado: (2018)

Synthesis of Two Methotrexate Prodrugs for Optimizing Drug Loading into Liposomes
por: Di Francesco, Valentina, et al.
Publicado: (2021)

Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer’s Disease
por: Hey, John A., et al.
Publicado: (2017)

Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits
por: Roy Chowdhury, Uttio, et al.
Publicado: (2020)

Design of Optimized Hypoxia-Activated Prodrugs Using Pharmacokinetic/Pharmacodynamic Modeling
por: Foehrenbacher, Annika, et al.
Publicado: (2013)

Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques
por: McMillan, JoEllyn, et al.
Publicado: (2017)

Pharmacokinetics of Temsavir, the Active Moiety of the Prodrug Fostemsavir, in Subjects with Hepatic Impairment
por: Sevinsky, Heather, et al.
Publicado: (2017)

Enhanced Cellular Uptake and Pharmacokinetic Characteristics of Doxorubicin-Valine Amide Prodrug
por: Park, Yohan, et al.
Publicado: (2016)

Pharmacokinetic/Pharmacodynamic Determination and Preclinical Pharmacokinetics of the β-Lactamase Inhibitor ETX1317 and Its Orally Available Prodrug ETX0282
por: O’Donnell, John, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ospqbp2c06rfapak604bk7qalb