Repeated Oral Administration of Oleanolic Acid Produces Cholestatic Liver Injury in Mice

Oleanolic acid (OA) is a triterpenoid and a fantastic molecule with many beneficial effects. However, high-doses and long-term use can produce adverse effects. This study aimed to characterize the hepatotoxic potential of OA. Mice were given OA at doses of 100–3,000 µmol/kg (45–1,350 mg/kg), po for...

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Detalles Bibliográficos
Autores principales: Lu, Yuan-Fu, Wan, Xiao-Li, Xu, Yasha, Liu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270117/
https://www.ncbi.nlm.nih.gov/pubmed/23470335
http://dx.doi.org/10.3390/molecules18033060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270117/
https://www.ncbi.nlm.nih.gov/pubmed/23470335
http://dx.doi.org/10.3390/molecules18033060

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