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Application of Reductive (13)C-Methylation of Lysines to Enhance the Sensitivity of Conventional NMR Methods
NMR is commonly used to investigate macromolecular interactions. However, sensitivity problems hamper its use for studying such interactions at low physiologically relevant concentrations. At high concentrations, proteins or peptides tend to aggregate. In order to overcome this problem, we make use...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270119/ https://www.ncbi.nlm.nih.gov/pubmed/23778120 http://dx.doi.org/10.3390/molecules18067103 |