C-5 Hydroxyethyl and Hydroxypropyl Acyclonucleosides as Substrates for Thymidine Kinase of Herpes Simplex Virus Type 1 (HSV-1 TK): Syntheses and Biological Evaluation

The efficient syntheses of 5-(2-hydroxyethyl)- and 5-(3-hydroxypropyl)-substituted pyrimidine derivatives bearing 2,3-dihydroxypropyl, acyclovir-, ganciclovir- and penciclovir-like side chains are reported. A synthetic approach that included the alkylation of an N-anionic-5-substituted pyrimidine in...

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Detalles Bibliográficos
Autores principales: Meščić, Andrijana, Krištafor, Svjetlana, Novaković, Ivana, Osmanović, Amar, Müller, Ursina, Završnik, Davorka, Ametamey, Simon M., Scapozza, Leonardo, Raić-Malić, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270122/
https://www.ncbi.nlm.nih.gov/pubmed/23644977
http://dx.doi.org/10.3390/molecules18055104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270122/
https://www.ncbi.nlm.nih.gov/pubmed/23644977
http://dx.doi.org/10.3390/molecules18055104

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