Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents

Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one (5) exhibited a remarkable ant...

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Detalles Bibliográficos
Autores principales: Derita, Marcos, del Olmo, Esther, Barboza, Bianca, García-Cadenas, Ana Esther, López-Pérez, José Luis, Andújar, Sebastián, Enriz, Daniel, Zacchino, Susana, San Feliciano, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270128/
https://www.ncbi.nlm.nih.gov/pubmed/23507777
http://dx.doi.org/10.3390/molecules18033479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270128/
https://www.ncbi.nlm.nih.gov/pubmed/23507777
http://dx.doi.org/10.3390/molecules18033479

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