Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

A series of novel 3-benzisoxazolyl-4-indolyl-maleimides were synthesized and evaluated for their GSK-3β inhibitory activity. Most compounds exhibited high inhibitory potency towards GSK-3β. Among them, compound 7j with an IC(50) value of 0.73 nM was the most promising GSK-3β inhibitor. Preliminary s...

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Detalles Bibliográficos
Autores principales: Ye, Qing, Li, Meng, Zhou, Yubo, Pang, Tao, Xu, Lei, Cao, Jiayi, Han, Liang, Li, Yujin, Wang, Weisi, Gao, Jianrong, Li, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270165/
https://www.ncbi.nlm.nih.gov/pubmed/23669633
http://dx.doi.org/10.3390/molecules18055498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270165/
https://www.ncbi.nlm.nih.gov/pubmed/23669633
http://dx.doi.org/10.3390/molecules18055498

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