Cyclooxygenase-2 (COX-2) Inhibition Constrains Indoleamine 2,3-Dioxygenase 1 (IDO1) Activity in Acute Myeloid Leukaemia Cells

Indoleamine 2,3-dioxygenase 1 (IDO1) metabolizes L-tryptophan to kynurenines (KYN), inducing T-cell suppression either directly or by altering antigen-presenting-cell function. Cyclooxygenase (COX)-2, the rate-limiting enzyme in the synthesis of prostaglandins, is over-expressed by several tumours....

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Detalles Bibliográficos
Autores principales: Iachininoto, Maria Grazia, Nuzzolo, Eugenia Rosa, Bonanno, Giuseppina, Mariotti, Andrea, Procoli, Annabella, Locatelli, Franco, Cristofaro, Raimondo De, Rutella, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270179/
https://www.ncbi.nlm.nih.gov/pubmed/23973990
http://dx.doi.org/10.3390/molecules180910132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270179/
https://www.ncbi.nlm.nih.gov/pubmed/23973990
http://dx.doi.org/10.3390/molecules180910132

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