Template-Based de Novo Design for Type II Kinase Inhibitors and Its Extended Application to Acetylcholinesterase Inhibitors

There is a compelling need to discover type II inhibitors targeting the unique DFG-out inactive kinase conformation since they are likely to possess greater potency and selectivity relative to traditional type I inhibitors. Using a known inhibitor, such as a currently available and approved drug or...

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Detalles Bibliográficos
Autores principales: Su, Bo-Han, Huang, Yi-Syuan, Chang, Chia-Yun, Tu, Yi-Shu, Tseng, Yufeng J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270190/
https://www.ncbi.nlm.nih.gov/pubmed/24184819
http://dx.doi.org/10.3390/molecules181113487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270190/
https://www.ncbi.nlm.nih.gov/pubmed/24184819
http://dx.doi.org/10.3390/molecules181113487

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