A 3D QSAR Study of Betulinic Acid Derivatives as Anti-Tumor Agents Using Topomer CoMFA: Model Building Studies and Experimental Verification

Betulinic acid (BA) is a natural product that exerts its cytotoxicity against various malignant carcinomas without side effects by triggering the mitochondrial pathway to apoptosis. Betulin (BE), the 28-hydroxyl analog of BA, is present in large amounts (up to 30% dry weight) in the outer bark of bi...

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Detalles Bibliográficos
Autores principales: Ding, Weimin, Sun, Miao, Luo, Shaman, Xu, Tao, Cao, Yibo, Yan, Xiufeng, Wang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270193/
https://www.ncbi.nlm.nih.gov/pubmed/23973995
http://dx.doi.org/10.3390/molecules180910228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270193/
https://www.ncbi.nlm.nih.gov/pubmed/23973995
http://dx.doi.org/10.3390/molecules180910228

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