Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives

An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides severa...

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Detalles Bibliográficos
Autores principales: Yang, Jinming, Li, Qiang, Zhang, Juanjuan, Lin, Wei, Wang, Juxian, Wang, Yucheng, Huang, Zhibin, Shi, Daqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270196/
https://www.ncbi.nlm.nih.gov/pubmed/24287988
http://dx.doi.org/10.3390/molecules181214519
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author Yang, Jinming
Li, Qiang
Zhang, Juanjuan
Lin, Wei
Wang, Juxian
Wang, Yucheng
Huang, Zhibin
Shi, Daqing
author_facet Yang, Jinming
Li, Qiang
Zhang, Juanjuan
Lin, Wei
Wang, Juxian
Wang, Yucheng
Huang, Zhibin
Shi, Daqing
author_sort Yang, Jinming
collection PubMed
description An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.
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spelling pubmed-62701962018-12-20 Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives Yang, Jinming Li, Qiang Zhang, Juanjuan Lin, Wei Wang, Juxian Wang, Yucheng Huang, Zhibin Shi, Daqing Molecules Article An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure. MDPI 2013-11-25 /pmc/articles/PMC6270196/ /pubmed/24287988 http://dx.doi.org/10.3390/molecules181214519 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yang, Jinming
Li, Qiang
Zhang, Juanjuan
Lin, Wei
Wang, Juxian
Wang, Yucheng
Huang, Zhibin
Shi, Daqing
Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives
title Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives
title_full Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives
title_fullStr Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives
title_full_unstemmed Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives
title_short Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives
title_sort ultrasound-promoted one-pot, four-component synthesis of pyridin-2(1h)-one derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270196/
https://www.ncbi.nlm.nih.gov/pubmed/24287988
http://dx.doi.org/10.3390/molecules181214519
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