Factors Influencing the Antifolate Activity of Synthetic Tea-Derived Catechins

Novel tea catechin derivatives have been synthesized, and a structure-activity study, related to the capacity of these and other polyphenols to bind dihydrofolate reductase (DHFR), has been performed. The data showed an effective binding between all molecules and the free enzyme, and the dissociatio...

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Detalles Bibliográficos
Autores principales: Sáez-Ayala, Magalí, Fernández-Pérez, María Piedad, Chazarra, Soledad, Mchedlishvili, Nani, Tárraga-Tomás, Alberto, Rodríguez-López, José Neptuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270263/
https://www.ncbi.nlm.nih.gov/pubmed/23863773
http://dx.doi.org/10.3390/molecules18078319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270263/
https://www.ncbi.nlm.nih.gov/pubmed/23863773
http://dx.doi.org/10.3390/molecules18078319

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