Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP and triggers the secretion of several proinflammatory substances, such as IL-1β, IL-18, TNF-α, and nitric oxide. Recently, several preclinical studies have demonstrated that this receptor participates i...

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Detalles Bibliográficos
Autores principales: Alves, Luiz Anastacio, Bezerra, Rômulo José Soares, Faria, Robson Xavier, Ferreira, Leonardo Gomes Braga, da Silva Frutuoso, Valber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270334/
https://www.ncbi.nlm.nih.gov/pubmed/24013409
http://dx.doi.org/10.3390/molecules180910953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270334/
https://www.ncbi.nlm.nih.gov/pubmed/24013409
http://dx.doi.org/10.3390/molecules180910953

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