Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP and triggers the secretion of several proinflammatory substances, such as IL-1β, IL-18, TNF-α, and nitric oxide. Recently, several preclinical studies have demonstrated that this receptor participates i...

Descripción completa

Detalles Bibliográficos
Autores principales: Alves, Luiz Anastacio, Bezerra, Rômulo José Soares, Faria, Robson Xavier, Ferreira, Leonardo Gomes Braga, da Silva Frutuoso, Valber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270334/
https://www.ncbi.nlm.nih.gov/pubmed/24013409
http://dx.doi.org/10.3390/molecules180910953
_version_ 1783376675715678208
author Alves, Luiz Anastacio
Bezerra, Rômulo José Soares
Faria, Robson Xavier
Ferreira, Leonardo Gomes Braga
da Silva Frutuoso, Valber
author_facet Alves, Luiz Anastacio
Bezerra, Rômulo José Soares
Faria, Robson Xavier
Ferreira, Leonardo Gomes Braga
da Silva Frutuoso, Valber
author_sort Alves, Luiz Anastacio
collection PubMed
description The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP and triggers the secretion of several proinflammatory substances, such as IL-1β, IL-18, TNF-α, and nitric oxide. Recently, several preclinical studies have demonstrated that this receptor participates in inflammation and pain mechanisms. Taken together, these results indicate that P2X7R is a promising pharmacological target, and compounds that modulate the function of this receptor show potential as new anti-inflammatory medicines. In this review, we discuss aspects of P2X7R pharmacology and the participation of this protein in inflammation and pain and provide an overview of some promising compounds that have been tested as antagonists of P2X7R, with clinical applicability.
format Online
Article
Text
id pubmed-6270334
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62703342018-12-18 Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain Alves, Luiz Anastacio Bezerra, Rômulo José Soares Faria, Robson Xavier Ferreira, Leonardo Gomes Braga da Silva Frutuoso, Valber Molecules Review The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP and triggers the secretion of several proinflammatory substances, such as IL-1β, IL-18, TNF-α, and nitric oxide. Recently, several preclinical studies have demonstrated that this receptor participates in inflammation and pain mechanisms. Taken together, these results indicate that P2X7R is a promising pharmacological target, and compounds that modulate the function of this receptor show potential as new anti-inflammatory medicines. In this review, we discuss aspects of P2X7R pharmacology and the participation of this protein in inflammation and pain and provide an overview of some promising compounds that have been tested as antagonists of P2X7R, with clinical applicability. MDPI 2013-09-05 /pmc/articles/PMC6270334/ /pubmed/24013409 http://dx.doi.org/10.3390/molecules180910953 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Alves, Luiz Anastacio
Bezerra, Rômulo José Soares
Faria, Robson Xavier
Ferreira, Leonardo Gomes Braga
da Silva Frutuoso, Valber
Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain
title Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain
title_full Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain
title_fullStr Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain
title_full_unstemmed Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain
title_short Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain
title_sort physiological roles and potential therapeutic applications of the p2x7 receptor in inflammation and pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270334/
https://www.ncbi.nlm.nih.gov/pubmed/24013409
http://dx.doi.org/10.3390/molecules180910953
work_keys_str_mv AT alvesluizanastacio physiologicalrolesandpotentialtherapeuticapplicationsofthep2x7receptorininflammationandpain
AT bezerraromulojosesoares physiologicalrolesandpotentialtherapeuticapplicationsofthep2x7receptorininflammationandpain
AT fariarobsonxavier physiologicalrolesandpotentialtherapeuticapplicationsofthep2x7receptorininflammationandpain
AT ferreiraleonardogomesbraga physiologicalrolesandpotentialtherapeuticapplicationsofthep2x7receptorininflammationandpain
AT dasilvafrutuosovalber physiologicalrolesandpotentialtherapeuticapplicationsofthep2x7receptorininflammationandpain

Ejemplares similares