A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction

An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved proc...

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Autores principales: He, Jun, Ouyang, Guang, Yuan, Zhixiang, Tong, Rongsheng, Shi, Jianyou, Ouyang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270352/
https://www.ncbi.nlm.nih.gov/pubmed/23644979
http://dx.doi.org/10.3390/molecules18055142
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author He, Jun
Ouyang, Guang
Yuan, Zhixiang
Tong, Rongsheng
Shi, Jianyou
Ouyang, Liang
author_facet He, Jun
Ouyang, Guang
Yuan, Zhixiang
Tong, Rongsheng
Shi, Jianyou
Ouyang, Liang
author_sort He, Jun
collection PubMed
description An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
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spelling pubmed-62703522018-12-14 A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction He, Jun Ouyang, Guang Yuan, Zhixiang Tong, Rongsheng Shi, Jianyou Ouyang, Liang Molecules Article An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity. MDPI 2013-05-03 /pmc/articles/PMC6270352/ /pubmed/23644979 http://dx.doi.org/10.3390/molecules18055142 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
He, Jun
Ouyang, Guang
Yuan, Zhixiang
Tong, Rongsheng
Shi, Jianyou
Ouyang, Liang
A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
title A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
title_full A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
title_fullStr A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
title_full_unstemmed A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
title_short A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
title_sort facile synthesis of functionalized dispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270352/
https://www.ncbi.nlm.nih.gov/pubmed/23644979
http://dx.doi.org/10.3390/molecules18055142
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