Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases

We synthesized two series of androstane derivatives as inhibitors of type 3 and type 5 17β-hydroxysteroid dehydrogenases (17β-HSDs). In the first series, four monospiro derivatives at position C17 were prepared from androsterone (ADT) or epi-ADT. After the protection of the alcohol at C3, the C17-ke...

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Detalles Bibliográficos
Autores principales: Djigoué, Guy Bertrand, Ngatcha, Béatrice Tchédam, Roy, Jenny, Poirier, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270367/
https://www.ncbi.nlm.nih.gov/pubmed/23344201
http://dx.doi.org/10.3390/molecules18010914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270367/
https://www.ncbi.nlm.nih.gov/pubmed/23344201
http://dx.doi.org/10.3390/molecules18010914

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