Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression

With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [(18)F]fluorine radiolabeled pyrimidine with 4-hydroxy-3-(hydroxymethyl)butyl side chain at N-1 (HHB-5-[(18...

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Detalles Bibliográficos
Autores principales: Meščić, Andrijana, Betzel, Thomas, Müller, Adrienne, Slavik, Roger, Čermak, Stjepko, Raić-Malić, Silvana, Ametamey, Simon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270388/
https://www.ncbi.nlm.nih.gov/pubmed/23877048
http://dx.doi.org/10.3390/molecules18078535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270388/
https://www.ncbi.nlm.nih.gov/pubmed/23877048
http://dx.doi.org/10.3390/molecules18078535

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